Kevan M. Shokat - 专业嘉宾邀请·会议出席服务·个人履历查看·商务合作对接简介
KevanMShokat,ProfessorofUniversityofCaliforniaSanFrancisco,SanFrancisco,USAResearchinhislaboratoryisfocusedonthediscoveryofnewchemicalbasedtoolstodeciphercellularsignalingnetworkswithanemphasisonproteinkinasesandmorerecently,GTPasesTheanalysisofsignaltransductionpathwayshasprovenchallengingusingthetraditionaltoolsofbiochemistry,genetics,andchemistryBiochemicalapproachesareoftenlimitedinutilitybecausesignalingnetworksspanfromthecellsurfacetothecontroloftranscriptionandtranslation,confoundingreconstitutioneffortsfrompurifiedproteinsGeneticapproachesallowspecificperturbationofsinglecomponentsinanintactcellororganism,yetareoftenconfoundedbytheemergentpropertiesofsignalingcascadesChemicalandpharmacologicalapproachesenablerapid,reversible,andgraded(dose-dependent)inactivationofsinglecomponentsinintactcellsororganismsUnfortunately,highlyselectivechemicalprobes(agonists,antagonists,traceablesubstrates,etc)ofproteinkinasesaredifficulttodevelopbecausethe500proteinkinasessharehighlyhomologousATPbindingpocketsMylaboratoryhassolvedthisfundamentalproblemforthelargestfamilyofenzymesinthehumangenome,proteinkinases,bydevelopmentofastrategybasedonacombinationofproteinengineeringandorganicsynthesisWehavetermedthisapproachchemicalgenetics